(+/-)-MUSCARINE CHLORIDE
- Product Name
- (+/-)-MUSCARINE CHLORIDE
- CAS No.
- 2936-25-6
- Chemical Name
- (+/-)-MUSCARINE CHLORIDE
- Synonyms
- (+)-MUSCARINE;Muscarinic chloride;DL-MUSCARINCHLORIDE);DL-MUSCARINECHLORIDE;(+/-)-MUSCARINE CHLORIDE;(±)-Muscarine chloride hydrate;(+/-)-muscarine chloride approx. 95%;(+/-)-MUSCARINE CHLORIDE SYNTHETIC >99%;Tetrahydro-4α-hydroxy-N,N,N,5β-tetramethyl-2β-furanmethanaminium;[(4α-Hydroxy-5β-methyltetrahydrofuran-2β-yl)methyl]trimethylaminium
- CBNumber
- CB9427721
- Molecular Formula
- C9H20ClNO2
- Formula Weight
- 209.71
- MOL File
- 2936-25-6.mol
(+/-)-MUSCARINE CHLORIDE Property
- storage temp.
- room temp
- solubility
- deionized water: ≥20mg/mL
- form
- powder
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M104
- Product name
- (±)-Muscarine chloride hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $167
- Updated
- 2024/03/01
- Product number
- M104
- Product name
- (±)-Muscarine chloride hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $537
- Updated
- 2024/03/01
- Product number
- M814005
- Product name
- (+/-)-MuscarineChloride
- Packaging
- 25mg
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- HBL0000023
- Product name
- (+/-)-MUSCARINE CHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $578
- Updated
- 2021/12/16
- Product number
- HBL0000023
- Product name
- (+/-)-MUSCARINE CHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $883.49
- Updated
- 2021/12/16
(+/-)-MUSCARINE CHLORIDE Chemical Properties,Usage,Production
Description
Muscarine is a natural alkaloid that is found in a number of wild mushrooms. Despite the fact that muscarine does not have any therapeutic value, it is of interest because of its expressed toxic properties, which made it one of the first systematically studied cholinomimetic substances. This compound was an underlying classification of cholinergic muscarinic receptors. The action of muscarine is similar to that of acetylcholine on peripheral autonomic effector organs, and atropine is an antagonist to it. Unlike acetylcholine, muscarine does not act on nicotinic receptors.
Uses
(+/-)-Muscarine Chloride is a muscarinic acteylcholine receptor agonist.
Biochem/physiol Actions
Muscarine is a potent agonist than acetylcholine and is not susceptible to degradation by cholinesterases. Muscarine administration results in muscle spasm especially in gut, bronchus and uterus.
Synthesis
Muscarine, 2-methyl-3-hydroxy-5-(N,N,N-trimethylammonium) methylentetrahydrofuran chloride (13.1.14), was first isolated from the poisonous mushrooms Amanita muscaria. It can be synthesized in various ways from completely different substances [16¨C24], particularly from 2,5-dimethyl-3-carboxymethylflurane, which undergoes a Curtius reaction, i.e. successive reactions with hydrazine and further with nitrous acid in isopropyl alcohol, which forms the urethane (13.1.9), the acidic hydrolysis of which gives 2,5-dimethyl-2H-furane-3 (13.1.10). Allylic bromination of this gives 2- methyl-5-bromomethyl-2H-furanone-3 (13.1.11), which is reacted with dimethylamine, forming 2-methyl-5-dimethylaminomethyl-2H-fluranone-3 (13.1.12). Reducing this compound leads to formation of 2-methyl-3-hydroxy-5-dimethylaminomethyltetrahydroflurane (13.1.13), the reaction of which with methyl chloride gives muscarine (13.1.14) as a mixture of stereoisomers.